Photoredox Catalysis for the Coupling Reaction of Nitrones with Aromatic Tertiary Amines
نویسندگان
چکیده
منابع مشابه
Dual catalysis. Merging photoredox with nickel catalysis: coupling of α-carboxyl sp³-carbons with aryl halides.
Over the past 40 years, transition metal catalysis has enabled bond formation between aryl and olefinic (sp(2)) carbons in a selective and predictable manner with high functional group tolerance. Couplings involving alkyl (sp(3)) carbons have proven more challenging. Here, we demonstrate that the synergistic combination of photoredox catalysis and nickel catalysis provides an alternative cross-...
متن کاملPhotoredox catalysis with visible light.
The increasing need for more efficient synthetic methods and sustainable processes can be seen as a major driving force for new inventions; it also stimulates the creative rethinking of known concepts, which, in turn, will lead to the development of innovative chemistry. For example, starting from the challenge to mimic and understand enzymatic transformations, organocatalysis has now become an...
متن کاملPhotoredox Cross-Coupling: Ir/Ni Dual Catalysis for the Synthesis of Benzylic Ethers
Single-electron transmetalation has emerged as an enabling paradigm for the cross-coupling of Csp(3) hybridized organotrifluoroborates. Cross-coupling of α-alkoxymethyltrifluoroborates with aryl and heteroaryl bromides has been demonstrated by employing dual catalysis with a combination of an iridium photoredox catalyst and a Ni cross-coupling catalyst. The resulting method enables the alkoxyme...
متن کاملAmine α-heteroarylation via photoredox catalysis: a homolytic aromatic substitution pathway.
The direct α-heteroarylation of tertiary amines has been accomplished via photoredox catalysis to generate valuable benzylic amine pharmacophores. A variety of five-and six-membered chloroheteroarenes are shown to function as viable coupling partners for the α-arylation of a diverse range of cyclic and acyclic amines. Evidence is provided for a homolytic aromatic substitution mechanism, in whic...
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ژورنال
عنوان ژورنال: Acta Chimica Sinica
سال: 2019
ISSN: 0567-7351
DOI: 10.6023/a19040150